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Our mission is to develop a large-scale production process for single glycoform monoclonal antibodies (Mabs) for therapeutic applications. There has been a rapid increase in demand for production of clinically-approved bio-pharmaceuticals for the treatment of human diseases. Monoclonal antibodies have dominated the bio-pharmaceutical markets with around 20 presently marketed, and over 200 in various stages of clinical trials. The estimated global sales of Mabs have increased from $300 million in 1997, to $25 billion in 2007 (Repligen annual report, 2008).